Effects of NR1H3 Genetic Variation on the Expression of Liver X Receptor α and the Progression of Alzheimer's Disease

Effects of NR1H3 Genetic Variation on the Expression of Liver X Receptor α and the Progression of Alzheimer's Disease

Alzheimer's disease (AD) has been postulated to involve defects in the clearance of amyloid-β (Aβ). Activation of liver X receptor α (LXRα) increases the expression of apolipoprotein E (ApoE) as well as cholesterol transporters ABCA1 and ABCG1, leading to augmented clearance of Aβ. We have prev...

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Bibliographic Details
Main Authors: Natunen, Teemu, Martiskainen, Henna, Sarajärvi, Timo, Helisalmi, Seppo, Pursiheimo, Juha-Pekka, Viswanathan, Jayashree, Laitinen, Marjo, Mäkinen, Petra, Kauppinen, Tarja, Rauramaa, Tuomas, Leinonen, Ville, Alafuzoff, Irina, Haapasalo, Annakaisa, Soininen, Hilkka, Hiltunen, Mikko
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835410/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835410/

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