Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy

Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer’s disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium home...

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Bibliographic Details
Main Authors: Kopeikina, Katherine J., Wegmann, Susanne, Pitstick, Rose, Carlson, George A., Bacskai, Brian J., Betensky, Rebecca A., Hyman, Bradley T., Spires-Jones, Tara L.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835324/