Alzheimer's disease: synapses gone cold

by Koffie, Robert M, Hyman, Bradley T, Spires-Jones, Tara L
Published 2011

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

by Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne, Nicholls, Samantha B, Spires-Jones, Tara L, Hyman, Bradley T
Published 2013

Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia

by Spires-Jones, Tara L., Fox, Leora M., Rozkalne, Anete, Pitstick, Rose, Carlson, George A., Kazantsev, Aleksey G.
Published 2012

Orchestrated experience-driven Arc/Arg3.1 responses are disrupted in a mouse model of Alzheimer’s disease

by Rudinskiy, Nikita, Hawkes, Jonathan M., Betensky, Rebecca A., Eguchi, Megumi, Yamaguchi, Shun, Spires-Jones, Tara L., Hyman, Bradley T.
Published 2012

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

by Tai, Hwan-Ching, Wang, Bo Y, Serrano-Pozo, Alberto, Frosch, Matthew P, Spires-Jones, Tara L, Hyman, Bradley T
Published 2014

T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice

by Meyer-Luehmann, Melanie, Mora, J Rodrigo, Mielke, Matthew, Spires-Jones, Tara L, de Calignon, Alix, von Andrian, Ulrich H, Hyman, Bradley T
Published 2011

Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy

by Kopeikina, Katherine J., Wegmann, Susanne, Pitstick, Rose, Carlson, George A., Bacskai, Brian J., Betensky, Rebecca A., Hyman, Bradley T., Spires-Jones, Tara L.
Published 2013

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses

by Rudinskiy, Nikita, Hawkes, Jonathan M, Wegmann, Susanne, Kuchibhotla, Kishore V, Muzikansky, Alona, Betensky, Rebecca A, Spires-Jones, Tara L, Hyman, Bradley T
Published 2014

Synapse Density and Dendritic Complexity Are Reduced in the Prefrontal Cortex following Seven Days of Forced Abstinence from Cocaine Self-Administration

by Rasakham, Khampaseuth, Schmidt, Heath D., Kay, Kevin, Huizenga, Megan N., Calcagno, Narghes, Pierce, R. Christopher, Spires-Jones, Tara L., Sadri-Vakili, Ghazaleh
Published 2014

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

by Pooler, Amy M, Polydoro, Manuela, Maury, Eduardo A, Nicholls, Samantha B, Reddy, Snigdha M, Wegmann, Susanne, William, Christopher, Saqran, Lubna, Cagsal-Getkin, Ozge, Pitstick, Rose, Beier, David R, Carlson, George A, Spires-Jones, Tara L, Hyman, Bradley T
Published 2015

Erratum to: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

by Henstridge, Christopher M., Jackson, Rosemary J., Kim, JeeSoo M., Herrmann, Abigail G., Wright, Ann K., Harris, Sarah E., Bastin, Mark E., Starr, John M., Wardlaw, Joanna, Gillingwater, Thomas H., Smith, Colin, McKenzie, Chris-Anne, Cox, Simon R., Deary, Ian J., Spires-Jones, Tara L.
Published 2015

Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

by Henstridge, Christopher M., Jackson, Rosemary J., Kim, JeeSoo M., Herrmann, Abigail G., Wright, Ann K., Harris, Sarah E., Bastin, Mark E., Starr, John M., Wardlaw, Joanna, Gillingwater, Thomas H., Smith, Colin, McKenzie, Chris-Anne, Cox, Simon R., Deary, Ian J., Spires-Jones, Tara L.
Published 2015

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

by Izzo, Nicholas J., Xu, Jinbin, Zeng, Chenbo, Kirk, Molly J., Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Cruchaga, Carlos, Goate, Alison, Cahill, Michael A., Arancio, Ottavio, Mach, Robert H., Craven, Rolf, Head, Elizabeth, LeVine, Harry, Spires-Jones, Tara L., Catalano, Susan M.
Published 2014