From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells

From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells

Elucidating the role of androgen deprivation in the transition from androgen-dependence to independence may enable the development of more specific therapeutic strategies against prostate cancer. Our previous in vitro model was employed to further assess the effects of continuous androgen-depriv...

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Main Authors: LIU, TIANCHENG, MENDES, DESIREE E., BERKMAN, CLIFFORD E.
Format: Online
Language:English
Published: D.A. Spandidos 201
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829778/
id pubmed-3829778
recordtype oai_dc
spelling pubmed-38297782013-11-18 From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells LIU, TIANCHENG MENDES, DESIREE E. BERKMAN, CLIFFORD E. Articles Elucidating the role of androgen deprivation in the transition from androgen-dependence to independence may enable the development of more specific therapeutic strategies against prostate cancer. Our previous in vitro model was employed to further assess the effects of continuous androgen-deprivation on prostate cancer cells (LNCaP) with respect to both androgen receptor (AR) and c-Met expression. The results indicated that long-term androgen deprivation resulted in a signaling pathway switch from AR to c-Met in androgen-sensitive cells, which was confirmed by immunofluorescence imaging and western blot analysis. This signaling pathway switch may be predictive of a more aggressive disease state following androgen deprivation therapy. D.A. Spandidos 2013 -07- 18 /pmc/articles/PMC3829778/ /pubmed/23877345 http://dx.doi.org/ 10.3892/ijo.2013.2020 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author LIU, TIANCHENG
MENDES, DESIREE E.
BERKMAN, CLIFFORD E.
spellingShingle LIU, TIANCHENG
MENDES, DESIREE E.
BERKMAN, CLIFFORD E.
From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells
author_facet LIU, TIANCHENG
MENDES, DESIREE E.
BERKMAN, CLIFFORD E.
author_sort LIU, TIANCHENG
title From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells
title_short From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells
title_full From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells
title_fullStr From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells
title_full_unstemmed From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells
title_sort from ar to c-met: androgen deprivation leads to a signaling pathway switch in prostate cancer cells
description Elucidating the role of androgen deprivation in the transition from androgen-dependence to independence may enable the development of more specific therapeutic strategies against prostate cancer. Our previous in vitro model was employed to further assess the effects of continuous androgen-deprivation on prostate cancer cells (LNCaP) with respect to both androgen receptor (AR) and c-Met expression. The results indicated that long-term androgen deprivation resulted in a signaling pathway switch from AR to c-Met in androgen-sensitive cells, which was confirmed by immunofluorescence imaging and western blot analysis. This signaling pathway switch may be predictive of a more aggressive disease state following androgen deprivation therapy.
publisher D.A. Spandidos
publishDate 201
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829778/
_version_ 1612027315698532352

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