From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells
Elucidating the role of androgen deprivation in the transition from androgen-dependence to independence may enable the development of more specific therapeutic strategies against prostate cancer. Our previous in vitro model was employed to further assess the effects of continuous androgen-depriv...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
D.A. Spandidos
201
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829778/ |
| Summary: | Elucidating the role of androgen deprivation in the transition from androgen-dependence to independence may enable the development of more specific therapeutic strategies against prostate cancer. Our previous
in vitro
model was employed to further assess the effects of continuous androgen-deprivation on prostate cancer cells (LNCaP) with respect to both androgen receptor (AR) and c-Met expression. The results indicated that long-term androgen deprivation resulted in a signaling pathway switch from AR to c-Met in androgen-sensitive cells, which was confirmed by immunofluorescence imaging and western blot analysis. This signaling pathway switch may be predictive of a more aggressive disease state following androgen deprivation therapy.
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