U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint
Chk1 is a conserved protein kinase originally identified in fission yeast, required to delay entry of cells with damaged or unreplicated DNA into mitosis. The requirement of Chk1 for both S and G2/M checkpoints has been elucidated while only few studies have connected Chk1 to the mitotic spindle che...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Blackwell Publishing Ltd
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828867/ |