Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and discoidin domain receptors (DDR), to fibrillar collagen. Whil...

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Bibliographic Details
Main Authors: Staudinger, Lisa A., Spano, Stephen J., Lee, Wilson, Coelho, Nuno, Rajshankar, Dhaarmini, Bendeck, Michelle P., Moriarty, Tara, McCulloch, Christopher A.
Format: Online
Language:English
Published: The Company of Biologists 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828761/