ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)
Collagen receptor DDR1 is shed upon collagen binding by ADAM10 metalloproteinase. This shedding controls the half-life of DDR1 signaling and cell migration on the collagen matrix. This event may be a part of a regulatory mechanism of microenvironment signaling.
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325837/ |