The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal

Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In...

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Main Authors:	Ferro, Anabela, Castro, Maria-José, Lemos, Carolina, Santos, Mónica, Sousa, Alda, Pereira-Monteiro, José, Sequeiros, Jorge, Maciel, Patrícia
Format:	Online
Language:	English
Published:	IOS Press 2008
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827821/

id	pubmed-3827821
recordtype	oai_dc
spelling	pubmed-38278212013-12-11 The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal Ferro, Anabela Castro, Maria-José Lemos, Carolina Santos, Mónica Sousa, Alda Pereira-Monteiro, José Sequeiros, Jorge Maciel, Patrícia Other Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population. IOS Press 2008 2008-10-22 /pmc/articles/PMC3827821/ /pubmed/18957721 http://dx.doi.org/10.1155/2008/178679 Text en Copyright © 2008 Hindawi Publishing Corporation.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ferro, Anabela Castro, Maria-José Lemos, Carolina Santos, Mónica Sousa, Alda Pereira-Monteiro, José Sequeiros, Jorge Maciel, Patrícia
spellingShingle	Ferro, Anabela Castro, Maria-José Lemos, Carolina Santos, Mónica Sousa, Alda Pereira-Monteiro, José Sequeiros, Jorge Maciel, Patrícia The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal
author_facet	Ferro, Anabela Castro, Maria-José Lemos, Carolina Santos, Mónica Sousa, Alda Pereira-Monteiro, José Sequeiros, Jorge Maciel, Patrícia
author_sort	Ferro, Anabela
title	The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal
title_short	The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal
title_full	The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal
title_fullStr	The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal
title_full_unstemmed	The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal
title_sort	c677t polymorphism in mthfr is not associated with migraine in portugal
description	Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.
publisher	IOS Press
publishDate	2008
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827821/
_version_	1612026748936912896

The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal

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