Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5
TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis through death receptors (DRs) 4 and/or 5 expressed on the surface of target cells. We have previously shown that deficiency of DR4 and DR5 on the surface membrane is a critical mechanism of cancer cell resistance to the recombinant huma...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824535/ |