Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), b...

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Bibliographic Details
Main Authors: Chianese, Giuseppina, Scala, Fernando, Calcinai, Barbara, Cerrano, Carlo, Dien, Henny A., Kaiser, Marcel, Tasdemir, Deniz, Taglialatela-Scafati, Orazio
Format: Online
Language:English
Published: MDPI 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806476/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806476/

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