Leucettamols, Bifunctionalized Marine Sphingoids, Act as Modulators of TRPA1 and TRPM8 Channels

Leucettamols, Bifunctionalized Marine Sphingoids, Act as Modulators of TRPA1 and TRPM8 Channels

Leucettamols, bifunctionalized sphingoid-like compounds obtained from a marine sponge Leucetta sp., act as non-electrophilic activators of the TRPA1 channel and potent inhibitors of the icilin-mediated activation of the TRPM8 channel, while they are inactive on CB1, CB2 and TRPV1 receptors. Leucetta...

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Bibliographic Details
Main Authors: Chianese, Giuseppina, Fattorusso, Ernesto, Putra, Masteria Yunovilsa, Calcinai, Barbara, Bavestrello, Giorgio, Moriello, Aniello Schiano, Petrocellis, Luciano De, Marzo, Vincenzo Di, Taglialatela-Scafati, Orazio
Format: Online
Language:English
Published: MDPI 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509527/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509527/

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