Linking genotype to phenotype on beads: high throughput selection of peptides with biological function

Although peptides are well recognised biological molecules in vivo, their selection from libraries is challenging because of relative low affinity whilst in linear conformation. We hypothesized that multiplexed peptides and DNA on the surface of beads would provide a platform for enhanced avidity an...

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Bibliographic Details
Main Authors: Huang, Li-Chieh, Pan, Xiaoyan, Yang, Hongbing, Wan, Lai Kin Derek, Stewart-Jones, Guillaume, Dorrell, Lucy, Ogg, Graham
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805977/