Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues
Although there is a therapeutic treatment to combat diabetes, the identification of agents that may deal with its more serious aspects is an important medical field for research. Diabetes, which contributes to the risk of cardiovascular disease, is associated with a low-grade chronic inflammation (i...
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| Format: | Online |
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Hindawi Publishing Corporation
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804143/ |
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pubmed-3804143 |
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pubmed-38041432013-11-04 Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues Son, Yong Lee, Ju Hwan Cheong, Yong-Kwan Chung, Hun-Taeg Pae, Hyun-Ock Review Article Although there is a therapeutic treatment to combat diabetes, the identification of agents that may deal with its more serious aspects is an important medical field for research. Diabetes, which contributes to the risk of cardiovascular disease, is associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of diabetes, agents and cellular molecules that can modulate these stress responses are emerging as potential targets for intervention and treatment of diabetic diseases. It has been recognized that heme oxygenase-1 (HO-1) plays an important role in cellular protection. Because HO-1 can reduce oxidative stress, inflammatory stress, and ER stress, in part by exerting antioxidant, anti-inflammatory, and antiapoptotic effects, HO-1 has been suggested to play important roles in pathogenesis of diabetes. In the present review, we will explore our current understanding of the protective mechanisms of HO-1 in diabetes and present some emerging therapeutic options for HO-1 expression in treating diabetic diseases, together with the therapeutic potential of curcumin analogues that have their ability to induce HO-1 expression. Hindawi Publishing Corporation 2013 2013-09-26 /pmc/articles/PMC3804143/ /pubmed/24191253 http://dx.doi.org/10.1155/2013/918039 Text en Copyright © 2013 Yong Son et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Son, Yong Lee, Ju Hwan Cheong, Yong-Kwan Chung, Hun-Taeg Pae, Hyun-Ock |
| spellingShingle |
Son, Yong Lee, Ju Hwan Cheong, Yong-Kwan Chung, Hun-Taeg Pae, Hyun-Ock Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues |
| author_facet |
Son, Yong Lee, Ju Hwan Cheong, Yong-Kwan Chung, Hun-Taeg Pae, Hyun-Ock |
| author_sort |
Son, Yong |
| title |
Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues |
| title_short |
Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues |
| title_full |
Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues |
| title_fullStr |
Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues |
| title_full_unstemmed |
Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues |
| title_sort |
antidiabetic potential of the heme oxygenase-1 inducer curcumin analogues |
| description |
Although there is a therapeutic treatment to combat diabetes, the identification of agents that may deal with its more serious aspects is an important medical field for research. Diabetes, which contributes to the risk of cardiovascular disease, is associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of diabetes, agents and cellular molecules that can modulate these stress responses are emerging as potential targets for intervention and treatment of diabetic diseases. It has been recognized that heme oxygenase-1 (HO-1) plays an important role in cellular protection. Because HO-1 can reduce oxidative stress, inflammatory stress, and ER stress, in part by exerting antioxidant, anti-inflammatory, and antiapoptotic effects, HO-1 has been suggested to play important roles in pathogenesis of diabetes. In the present review, we will explore our current understanding of the protective mechanisms of HO-1 in diabetes and present some emerging therapeutic options for HO-1 expression in treating diabetic diseases, together with the therapeutic potential of curcumin analogues that have their ability to induce HO-1 expression. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804143/ |
| _version_ |
1612019657188835328 |