Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations

Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations

Transactive response DNA-binding protein 43 (TDP-43) is a major pathological protein in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). There are many disease-associated mutations in TDP-43, and several cellular and animal models with ectopic overexpression of mutant TDP-43 ha...

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Bibliographic Details
Main Authors: Zhang, Zhijun, Almeida, Sandra, Lu, Yubing, Nishimura, Agnes L., Peng, Lingtao, Sun, Danqiong, Wu, Bei, Karydas, Anna M., Tartaglia, Maria C., Fong, Jamie C., Miller, Bruce L., Farese, Robert V., Moore, Melissa J., Shaw, Christopher E., Gao, Fen-Biao
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797144/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797144/

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