Indole prevents Escherichia coli cell division by modulating membrane potential

Indole is a bacterial signalling molecule that blocks E. coli cell division at concentrations of 3–5 mM. We have shown that indole is a proton ionophore and that this activity is key to the inhibition of division. By reducing the electrochemical potential across the cytoplasmic membrane of E. coli,...

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Main Authors:	Chimerel, Catalin, Field, Christopher M., Piñero-Fernandez, Silvia, Keyser, Ulrich F., Summers, David K.
Format:	Online
Language:	English
Published:	Elsevier Pub. Co 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793866/

id	pubmed-3793866
recordtype	oai_dc
spelling	pubmed-37938662013-10-10 Indole prevents Escherichia coli cell division by modulating membrane potential Chimerel, Catalin Field, Christopher M. Piñero-Fernandez, Silvia Keyser, Ulrich F. Summers, David K. Article Indole is a bacterial signalling molecule that blocks E. coli cell division at concentrations of 3–5 mM. We have shown that indole is a proton ionophore and that this activity is key to the inhibition of division. By reducing the electrochemical potential across the cytoplasmic membrane of E. coli, indole deactivates MinCD oscillation and prevents formation of the FtsZ ring that is a prerequisite for division. This is the first example of a natural ionophore regulating a key biological process. Our findings have implications for our understanding of membrane biology, bacterial cell cycle control and potentially for the design of antibiotics that target the cell membrane. Elsevier Pub. Co 2012-07 /pmc/articles/PMC3793866/ /pubmed/22387460 http://dx.doi.org/10.1016/j.bbamem.2012.02.022 Text en © 2012 Elsevier B.V. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chimerel, Catalin Field, Christopher M. Piñero-Fernandez, Silvia Keyser, Ulrich F. Summers, David K.
spellingShingle	Chimerel, Catalin Field, Christopher M. Piñero-Fernandez, Silvia Keyser, Ulrich F. Summers, David K. Indole prevents Escherichia coli cell division by modulating membrane potential
author_facet	Chimerel, Catalin Field, Christopher M. Piñero-Fernandez, Silvia Keyser, Ulrich F. Summers, David K.
author_sort	Chimerel, Catalin
title	Indole prevents Escherichia coli cell division by modulating membrane potential
title_short	Indole prevents Escherichia coli cell division by modulating membrane potential
title_full	Indole prevents Escherichia coli cell division by modulating membrane potential
title_fullStr	Indole prevents Escherichia coli cell division by modulating membrane potential
title_full_unstemmed	Indole prevents Escherichia coli cell division by modulating membrane potential
title_sort	indole prevents escherichia coli cell division by modulating membrane potential
description	Indole is a bacterial signalling molecule that blocks E. coli cell division at concentrations of 3–5 mM. We have shown that indole is a proton ionophore and that this activity is key to the inhibition of division. By reducing the electrochemical potential across the cytoplasmic membrane of E. coli, indole deactivates MinCD oscillation and prevents formation of the FtsZ ring that is a prerequisite for division. This is the first example of a natural ionophore regulating a key biological process. Our findings have implications for our understanding of membrane biology, bacterial cell cycle control and potentially for the design of antibiotics that target the cell membrane.
publisher	Elsevier Pub. Co
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793866/
_version_	1612017385353510912

Indole prevents Escherichia coli cell division by modulating membrane potential

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