Polyenylpyrrole Derivatives Inhibit NLRP3 Inflammasome Activation and Inflammatory Mediator Expression by Reducing Reactive Oxygen Species Production and Mitogen-Activated Protein Kinase Activation

Polyenylpyrrole Derivatives Inhibit NLRP3 Inflammasome Activation and Inflammatory Mediator Expression by Reducing Reactive Oxygen Species Production and Mitogen-Activated Protein Kinase Activation

Two polyenylpyrroles from a soil ascomycete Gymnoascus reessii were previously identified as hit compounds in screening for cytotoxicity against lung cancer cells. These compounds and various analogs, which have been previously synthesized and tested for anti-lung cancer cell activity, were tested f...

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Bibliographic Details
Main Authors: Hua, Kuo-Feng, Chou, Ju-Ching, Lam, Yulin, Tasi, Yu-Ling, Chen, Ann, Ka, Shuk-Man, Fang, Zhanxiong, Liu, May-Lan, Yang, Feng-Ling, Yang, Yu-Liang, Chiu, Yi-Chich, Wu, Shih-Hsiung
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792051/

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