Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout

MicroRNAs are small noncoding RNAs thought to have pivotal roles in numerous diseases and developmental processes. However, a growing body of literature indicates that in vivo elimination of these tiny RNAs usually has little to no observable consequence, suggesting functional redundancy with other...

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Main Authors:	Farmer, D’Juan T., Shariat, Nikki, Park, Chong Yon, Liu, Huey Jiin, Mavropoulos, Anastasia, McManus, Michael T.
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792019/

id	pubmed-3792019
recordtype	oai_dc
spelling	pubmed-37920192013-10-10 Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout Farmer, D’Juan T. Shariat, Nikki Park, Chong Yon Liu, Huey Jiin Mavropoulos, Anastasia McManus, Michael T. Research Article MicroRNAs are small noncoding RNAs thought to have pivotal roles in numerous diseases and developmental processes. However, a growing body of literature indicates that in vivo elimination of these tiny RNAs usually has little to no observable consequence, suggesting functional redundancy with other microRNAs or cellular pathways. We provide an in-depth analysis of miR-205 expression and define miR-205 as an epithelial-specific microRNA, and for the first time show that ablation of this microRNA knockout exhibits partially penetrant lethality in a constitutive mouse knockout model. Given the role of this microRNA in cancer and development, this mouse model will be an incredible reagent to study the function and mechanisms of miR-205 in epithelial tissue development and disease. Public Library of Science 2013-10-07 /pmc/articles/PMC3792019/ /pubmed/24116130 http://dx.doi.org/10.1371/journal.pone.0076634 Text en © 2013 Farmer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Farmer, D’Juan T. Shariat, Nikki Park, Chong Yon Liu, Huey Jiin Mavropoulos, Anastasia McManus, Michael T.
spellingShingle	Farmer, D’Juan T. Shariat, Nikki Park, Chong Yon Liu, Huey Jiin Mavropoulos, Anastasia McManus, Michael T. Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout
author_facet	Farmer, D’Juan T. Shariat, Nikki Park, Chong Yon Liu, Huey Jiin Mavropoulos, Anastasia McManus, Michael T.
author_sort	Farmer, D’Juan T.
title	Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout
title_short	Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout
title_full	Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout
title_fullStr	Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout
title_full_unstemmed	Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout
title_sort	partially penetrant postnatal lethality of an epithelial specific microrna in a mouse knockout
description	MicroRNAs are small noncoding RNAs thought to have pivotal roles in numerous diseases and developmental processes. However, a growing body of literature indicates that in vivo elimination of these tiny RNAs usually has little to no observable consequence, suggesting functional redundancy with other microRNAs or cellular pathways. We provide an in-depth analysis of miR-205 expression and define miR-205 as an epithelial-specific microRNA, and for the first time show that ablation of this microRNA knockout exhibits partially penetrant lethality in a constitutive mouse knockout model. Given the role of this microRNA in cancer and development, this mouse model will be an incredible reagent to study the function and mechanisms of miR-205 in epithelial tissue development and disease.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792019/
_version_	1612016767666749440

Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout

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