Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice

Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice

Background: Identifying genes that are essential for mouse embryonic development and survival through term is a powerful and unbiased way to discover possible genetic determinants of human developmental disorders. Characterising the changes in mouse embryos that result from ablation of lethal genes...

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Bibliographic Details
Main Authors: Wilson, Robert, Geyer, Stefan H., Reissig, Lukas, Rose, Julia, Szumska, Dorota, Hardman, Emily, Prin, Fabrice, McGuire, Christina, Ramirez-Solis, Ramiro, White, Jacqui, Galli, Antonella, Tudor, Catherine, Tuck, Elizabeth, Mazzeo, Cecilia Icoresi, Smith, James C., Robertson, Elizabeth, Adams, David J., Mohun, Timothy, Weninger, Wolfgang J.
Format: Online
Language:English
Published: F1000Research 2017
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159622/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159622/

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