Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics

A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C10 to C12-alkyl side chains display...

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Bibliographic Details
Main Authors: Krauss, Jürgen, Gratzl, Carina, Sturm, Verena, Müller, Christoph, Staudacher, Verena, Schmidt, Christoph Q., Bracher, Franz
Format: Online
Language:English
Published: Österreichische Apotheker-Verlagsgesellschaft 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791929/
Description
Summary:A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C10 to C12-alkyl side chains displayed significant antimycotic activity.