Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund–Thomson syndrome

Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund–Thomson syndrome

Rothmund–Thomson fibroblasts had replicative lifespans and growth rates within the range for normal fibroblasts; however, they show elevated levels of the stress-associated p38 MAP kinase, suggestive of stress during growth. Treatment with the p38 MAP kinase inhibitor SB203580 increased both lifespa...

Full description

Bibliographic Details
Main Authors: Davis, Terence, Tivey, Hannah S. E., Brook, Amy J. C., Grimstead, Julia W., Rokicki, Michal J., Kipling, David
Format: Online
Language:English
Published: Springer Netherlands 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776094/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776094/

Similar Items