p38 MAPK stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes
Werner Syndrome (WS) is a human segmental progeria resulting from mutations in a DNA helicase. WS fibroblasts have a shortened replicative capacity, an aged appearance, and activated p38 MAPK, features that can be modulated by inhibition of the p38 pathway. Loss of the WRNp RecQ helicase has been sh...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer Netherlands
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627027/ |