Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level

Nociceptive primary afferents release glutamate, activating postsynaptic glutamate receptors on spinal cord dorsal horn neurons. Glutamate receptors, both ionotropic and metabotropic, are also expressed on presynaptic terminals, where they regulate neurotransmitter release. During the last two decad...

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Main Author:	Bardoni, Rita
Format:	Online
Language:	English
Published:	Bentham Science Publishers 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763755/

id	pubmed-3763755
recordtype	oai_dc
spelling	pubmed-37637552014-03-01 Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level Bardoni, Rita Article Nociceptive primary afferents release glutamate, activating postsynaptic glutamate receptors on spinal cord dorsal horn neurons. Glutamate receptors, both ionotropic and metabotropic, are also expressed on presynaptic terminals, where they regulate neurotransmitter release. During the last two decades, a wide number of studies have characterized the properties of presynaptic glutamatergic receptors, particularly those expressed on primary afferent fibers. This review describes the subunit composition, distribution and function of presynaptic glutamate ionotropic (AMPA, NMDA, kainate) and metabotropic receptors expressed in rodent spinal cord dorsal horn. The role of presynaptic receptors in modulating nociceptive information in experimental models of acute and chronic pain will be also discussed. Bentham Science Publishers 2013-09 2013-09 /pmc/articles/PMC3763755/ /pubmed/24403871 http://dx.doi.org/10.2174/1570159X11311050002 Text en ©2013 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bardoni, Rita
spellingShingle	Bardoni, Rita Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
author_facet	Bardoni, Rita
author_sort	Bardoni, Rita
title	Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
title_short	Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
title_full	Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
title_fullStr	Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
title_full_unstemmed	Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
title_sort	role of presynaptic glutamate receptors in pain transmission at the spinal cord level
description	Nociceptive primary afferents release glutamate, activating postsynaptic glutamate receptors on spinal cord dorsal horn neurons. Glutamate receptors, both ionotropic and metabotropic, are also expressed on presynaptic terminals, where they regulate neurotransmitter release. During the last two decades, a wide number of studies have characterized the properties of presynaptic glutamatergic receptors, particularly those expressed on primary afferent fibers. This review describes the subunit composition, distribution and function of presynaptic glutamate ionotropic (AMPA, NMDA, kainate) and metabotropic receptors expressed in rodent spinal cord dorsal horn. The role of presynaptic receptors in modulating nociceptive information in experimental models of acute and chronic pain will be also discussed.
publisher	Bentham Science Publishers
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763755/
_version_	1612008580117954560

Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level

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