CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex

CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex

In the lymph node (LN) environment, chronic lymphocytic leukemia (CLL) cells display increased NF-κB activity compared with peripheral blood CLL cells, which contributes to chemoresistance. Antagonists of cellular inhibitor of apoptosis proteins (cIAPs) can induce apoptosis in various cancer cells i...

Full description

Bibliographic Details
Main Authors: Maas, C, Tromp, J M, van Laar, J, Thijssen, R, Elias, J A, Malara, A, Krippner-Heidenreich, A, Silke, J, van Oers, M HJ, Eldering, E
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763465/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763465/

Similar Items