Rebuilding Pluripotency from Primordial Germ Cells

Mammalian primordial germ cells (PGCs) are unipotent progenitors of the gametes. Nonetheless, they can give rise directly to pluripotent stem cells in vitro or during teratocarcinogenesis. This conversion is inconsistent, however, and has been difficult to study. Here, we delineate requirements for...

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Bibliographic Details
Main Authors: Leitch, Harry G., Nichols, Jennifer, Humphreys, Peter, Mulas, Carla, Martello, Graziano, Lee, Caroline, Jones, Ken, Surani, M. Azim, Smith, Austin
Format: Online
Language:English
Published: Elsevier 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757743/