Oxysterols in the pathogenesis of major chronic diseases☆
Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks...
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| Format: | Online |
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Elsevier
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757713/ |
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pubmed-37577132013-09-10 Oxysterols in the pathogenesis of major chronic diseases☆ Poli, Giuseppe Biasi, Fiorella Leonarduzzi, Gabriella Mini Review Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks and primary mechanisms of progression. Indeed, certain oxysterols exercise strong pro-oxidant and pro-inflammatory effects at concentrations detectable in the lesions typical of atherosclerosis, neurodegenerative diseases, inflammatory bowel diseases, age-related macular degeneration, and other pathological conditions characterized by altered cholesterol uptake and/or metabolism. Elsevier 2013-01-31 /pmc/articles/PMC3757713/ /pubmed/24024145 http://dx.doi.org/10.1016/j.redox.2012.12.001 Text en © 2013 The Authors http://creativecommons.org/licenses/BY-NC-SA/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Poli, Giuseppe Biasi, Fiorella Leonarduzzi, Gabriella |
| spellingShingle |
Poli, Giuseppe Biasi, Fiorella Leonarduzzi, Gabriella Oxysterols in the pathogenesis of major chronic diseases☆ |
| author_facet |
Poli, Giuseppe Biasi, Fiorella Leonarduzzi, Gabriella |
| author_sort |
Poli, Giuseppe |
| title |
Oxysterols in the pathogenesis of major chronic diseases☆ |
| title_short |
Oxysterols in the pathogenesis of major chronic diseases☆ |
| title_full |
Oxysterols in the pathogenesis of major chronic diseases☆ |
| title_fullStr |
Oxysterols in the pathogenesis of major chronic diseases☆ |
| title_full_unstemmed |
Oxysterols in the pathogenesis of major chronic diseases☆ |
| title_sort |
oxysterols in the pathogenesis of major chronic diseases☆ |
| description |
Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks and primary mechanisms of progression. Indeed, certain oxysterols exercise strong pro-oxidant and pro-inflammatory effects at concentrations detectable in the lesions typical of atherosclerosis, neurodegenerative diseases, inflammatory bowel diseases, age-related macular degeneration, and other pathological conditions characterized by altered cholesterol uptake and/or metabolism. |
| publisher |
Elsevier |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757713/ |
| _version_ |
1612007065445728256 |