Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo

Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo

Repair of large bone defects is a major challenge, requiring sustained stimulation to continually promote bone formation locally. Bone morphogenetic protein 2 (BMP-2) plays an important role in bone development. In an attempt to overcome this difficulty of bone repair, we created a delivery system t...

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Bibliographic Details
Main Authors: Qiao, Chunyan, Zhang, Kai, Jin, Han, Miao, Leiying, Shi, Ce, Liu, Xia, Yuan, Anliang, Liu, Jinzhong, Li, Daowei, Zheng, Changyu, Zhang, Guirong, Li, Xiangwei, Yang, Bai, Sun, Hongchen
Format: Online
Language:English
Published: Dove Medical Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748902/

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