Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes. Here we demonstrate a novel role for this pathway in directly regulating mitochondrial bioenerget...
| Main Authors: | , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Company of Biologists
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744067/ |