Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export
Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nu...
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| Format: | Online |
| Language: | English |
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MDPI
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738964/ |
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pubmed-3738964 |
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pubmed-37389642013-08-09 Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export Kuss, Sharon K. Mata, Miguel A. Zhang, Liang Fontoura, Beatriz M. A. Review Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses. MDPI 2013-07-18 /pmc/articles/PMC3738964/ /pubmed/23872491 http://dx.doi.org/10.3390/v5071824 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kuss, Sharon K. Mata, Miguel A. Zhang, Liang Fontoura, Beatriz M. A. |
| spellingShingle |
Kuss, Sharon K. Mata, Miguel A. Zhang, Liang Fontoura, Beatriz M. A. Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export |
| author_facet |
Kuss, Sharon K. Mata, Miguel A. Zhang, Liang Fontoura, Beatriz M. A. |
| author_sort |
Kuss, Sharon K. |
| title |
Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export |
| title_short |
Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export |
| title_full |
Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export |
| title_fullStr |
Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export |
| title_full_unstemmed |
Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export |
| title_sort |
nuclear imprisonment: viral strategies to arrest host mrna nuclear export |
| description |
Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses. |
| publisher |
MDPI |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738964/ |
| _version_ |
1612002021268783104 |