Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

Altering pyrimidine levels in influenza virus– or VSV-infected cells reverses the inhibitory effect of viral proteins NS1 and M on host mRNA nuclear export, restoring expression of host antiviral factors.

Bibliographic Details
Main Authors: Zhang, Liang, Das, Priyabrata, Schmolke, Mirco, Manicassamy, Balaji, Wang, Yaming, Deng, Xiaoyi, Cai, Ling, Tu, Benjamin P., Forst, Christian V., Roth, Michael G., Levy, David E., García-Sastre, Adolfo, de Brabander, Jef, Phillips, Margaret A., Fontoura, Beatriz M.A.
Format: Online
Language:English
Published: The Rockefeller University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275370/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275370/

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