Hypoxia-Ischemia or Excitotoxin-Induced Tissue Plasminogen Activator- Dependent Gelatinase Activation in Mice Neonate Brain Microvessels

Hypoxia-ischemia (HI) and excitotoxicity are validated causes of neonatal brain injuries and tissue plasminogen activator (t-PA) participates in the processes through proteolytic and receptor-mediated pathways. Brain microvascular endothelial cells from neonates in culture, contain and release more...

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Bibliographic Details
Main Authors: Omouendze, Priscilla L., Henry, Vincent J., Porte, Baptiste, Dupré, Nicolas, Carmeliet, Peter, Gonzalez, Bruno J., Marret, Stéphane, Leroux, Philippe
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735506/