Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support

In a large brain-imaging study, a multinational consortium has recently identified a common genetic variation in rs7294919 being associated with hippocampal volume. Here, we explored whether this quantitative trait locus also affects hippocampal function using a previously established reliable neuro...

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Main Authors:	Erk, S, Meyer-Lindenberg, A, Schmierer, P, Grimm, O, Tost, H, Mühleisen, T, Mattheisen, M, Seiferth, N, Cichon, S, Rietschel, M, Nöthen, M M, Heinz, A, Walter, H
Format:	Online
Language:	English
Published:	Nature Publishing Group 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731789/

id	pubmed-3731789
recordtype	oai_dc
spelling	pubmed-37317892013-08-02 Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support Erk, S Meyer-Lindenberg, A Schmierer, P Grimm, O Tost, H Mühleisen, T Mattheisen, M Seiferth, N Cichon, S Rietschel, M Nöthen, M M Heinz, A Walter, H Original Article In a large brain-imaging study, a multinational consortium has recently identified a common genetic variation in rs7294919 being associated with hippocampal volume. Here, we explored whether this quantitative trait locus also affects hippocampal function using a previously established reliable neuroimaging paradigm. We observed a significant effect of rs7294919 variation in the right hippocampus showing that hippocampal activation increased with the number of risk alleles. Furthermore, the risk allele was associated with decreased performance in a verbal learning and memory task. By showing that this single-nucleotide polymorphism also relates to behavioral difference and underlying brain activation in memory, our findings support the idea that rs7294919 may affect the individual capacity to resist disease in terms of diminishing or boosting hippocampal resources. Nature Publishing Group 2013-07 2013-07-23 /pmc/articles/PMC3731789/ /pubmed/23880882 http://dx.doi.org/10.1038/tp.2013.57 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Erk, S Meyer-Lindenberg, A Schmierer, P Grimm, O Tost, H Mühleisen, T Mattheisen, M Seiferth, N Cichon, S Rietschel, M Nöthen, M M Heinz, A Walter, H
spellingShingle	Erk, S Meyer-Lindenberg, A Schmierer, P Grimm, O Tost, H Mühleisen, T Mattheisen, M Seiferth, N Cichon, S Rietschel, M Nöthen, M M Heinz, A Walter, H Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support
author_facet	Erk, S Meyer-Lindenberg, A Schmierer, P Grimm, O Tost, H Mühleisen, T Mattheisen, M Seiferth, N Cichon, S Rietschel, M Nöthen, M M Heinz, A Walter, H
author_sort	Erk, S
title	Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support
title_short	Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support
title_full	Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support
title_fullStr	Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support
title_full_unstemmed	Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support
title_sort	functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support
description	In a large brain-imaging study, a multinational consortium has recently identified a common genetic variation in rs7294919 being associated with hippocampal volume. Here, we explored whether this quantitative trait locus also affects hippocampal function using a previously established reliable neuroimaging paradigm. We observed a significant effect of rs7294919 variation in the right hippocampus showing that hippocampal activation increased with the number of risk alleles. Furthermore, the risk allele was associated with decreased performance in a verbal learning and memory task. By showing that this single-nucleotide polymorphism also relates to behavioral difference and underlying brain activation in memory, our findings support the idea that rs7294919 may affect the individual capacity to resist disease in terms of diminishing or boosting hippocampal resources.
publisher	Nature Publishing Group
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731789/
_version_	1612000090685177856

Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support

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