Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling

Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling

The RAF kinase family is essential in mediating signal transduction from RAS to ERK. BRAF constitutively active mutations correlate with human cancer development. However, the precise molecular regulation of BRAF activation is not fully understood. Here we report that BRAF is modified by Lys63-linke...

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Main Authors: An, Lei, Jia, Wei, Yu, Yang, Zou, Ning, Liang, Li, Zhao, Yanling, Fan, Yihui, Cheng, Jin, Shi, Zhongcheng, Xu, Gufeng, Li, Grace, Yang, Jianhua, Zhang, Hong
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731650/

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