Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood
Elevation of serum IgE levels has long been associated with allergic diseases. Many genes have been linked to IgE production, but few have been linked to the developmental aspects of genetic association with IgE production. To clarify developmental genetic association, we investigated what genes and...
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| Format: | Online |
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Public Library of Science
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731352/ |
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pubmed-37313522013-08-09 Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood Chang, Jen-Chieh Kuo, Ho-Chang Hsu, Te-Yao Ou, Chia-Yu Liu, Chieh-An Chuang, Hau Liang, Hsiu-Mei Huang, Hurng-Wern Yang, Kuender D. Research Article Elevation of serum IgE levels has long been associated with allergic diseases. Many genes have been linked to IgE production, but few have been linked to the developmental aspects of genetic association with IgE production. To clarify developmental genetic association, we investigated what genes and gene-gene interactions affect IgE levels among fetus, infancy and childhood in Taiwan individuals. A birth cohort of 571 children with completion of IgE measurements from newborn to 1.5, 3, and 6 years of age was subject to genetic association analysis on the 384-customized SNPs of 159 allergy candidate genes. Fifty-three SNPs in 37 genes on innate and adaptive immunity, and stress and response were associated with IgE production. Polymorphisms of the IL13, and the HLA-DPA1 and HLA-DQA1 were, respectively, the most significantly associated with the IgE production at newborn and 6 years of age. Analyses of gene-gene interactions indentified that the combination of NPSR1, rs324981 TT with FGF1, rs2282797 CC had the highest risk (85.7%) of IgE elevation at 1.5 years of age (P = 1.46×10−4). The combination of IL13, CYFIP2 and PDE2A was significantly associated with IgE elevation at 3 years of age (P = 5.98×10−7), and the combination of CLEC2D, COLEC11 and CCL2 was significantly associated with IgE elevation at 6 years of age (P = 6.65×10−7). Our study showed that the genetic association profiles of the IgE production among fetus, infancy and childhood are different. Genetic markers for early prediction and prevention of allergic sensitization may rely on age-based genetic association profiles. Public Library of Science 2013-08-01 /pmc/articles/PMC3731352/ /pubmed/23936416 http://dx.doi.org/10.1371/journal.pone.0070362 Text en © 2013 Chang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chang, Jen-Chieh Kuo, Ho-Chang Hsu, Te-Yao Ou, Chia-Yu Liu, Chieh-An Chuang, Hau Liang, Hsiu-Mei Huang, Hurng-Wern Yang, Kuender D. |
| spellingShingle |
Chang, Jen-Chieh Kuo, Ho-Chang Hsu, Te-Yao Ou, Chia-Yu Liu, Chieh-An Chuang, Hau Liang, Hsiu-Mei Huang, Hurng-Wern Yang, Kuender D. Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood |
| author_facet |
Chang, Jen-Chieh Kuo, Ho-Chang Hsu, Te-Yao Ou, Chia-Yu Liu, Chieh-An Chuang, Hau Liang, Hsiu-Mei Huang, Hurng-Wern Yang, Kuender D. |
| author_sort |
Chang, Jen-Chieh |
| title |
Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood |
| title_short |
Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood |
| title_full |
Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood |
| title_fullStr |
Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood |
| title_full_unstemmed |
Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood |
| title_sort |
different genetic associations of the ige production among fetus, infancy and childhood |
| description |
Elevation of serum IgE levels has long been associated with allergic diseases. Many genes have been linked to IgE production, but few have been linked to the developmental aspects of genetic association with IgE production. To clarify developmental genetic association, we investigated what genes and gene-gene interactions affect IgE levels among fetus, infancy and childhood in Taiwan individuals. A birth cohort of 571 children with completion of IgE measurements from newborn to 1.5, 3, and 6 years of age was subject to genetic association analysis on the 384-customized SNPs of 159 allergy candidate genes. Fifty-three SNPs in 37 genes on innate and adaptive immunity, and stress and response were associated with IgE production. Polymorphisms of the IL13, and the HLA-DPA1 and HLA-DQA1 were, respectively, the most significantly associated with the IgE production at newborn and 6 years of age. Analyses of gene-gene interactions indentified that the combination of NPSR1, rs324981 TT with FGF1, rs2282797 CC had the highest risk (85.7%) of IgE elevation at 1.5 years of age (P = 1.46×10−4). The combination of IL13, CYFIP2 and PDE2A was significantly associated with IgE elevation at 3 years of age (P = 5.98×10−7), and the combination of CLEC2D, COLEC11 and CCL2 was significantly associated with IgE elevation at 6 years of age (P = 6.65×10−7). Our study showed that the genetic association profiles of the IgE production among fetus, infancy and childhood are different. Genetic markers for early prediction and prevention of allergic sensitization may rely on age-based genetic association profiles. |
| publisher |
Public Library of Science |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731352/ |
| _version_ |
1611999985568579584 |