Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. Therefore, we tested whether the aggregate effect of these loci is diminished in...

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Main Authors: Ahmad, Shafqat, Rukh, Gull, Varga, Tibor V., Ali, Ashfaq, Kurbasic, Azra, Shungin, Dmitry, Ericson, Ulrika, Koivula, Robert W., Chu, Audrey Y., Rose, Lynda M., Ganna, Andrea, Qi, Qibin, Stančáková, Alena, Sandholt, Camilla H., Elks, Cathy E., Curhan, Gary, Jensen, Majken K., Tamimi, Rulla M., Allin, Kristine H., Jørgensen, Torben, Brage, Soren, Langenberg, Claudia, Aadahl, Mette, Grarup, Niels, Linneberg, Allan, Paré, Guillaume, Magnusson, Patrik K. E., Pedersen, Nancy L., Boehnke, Michael, Hamsten, Anders, Mohlke, Karen L., Pasquale, Louis T., Pedersen, Oluf, Scott, Robert A., Ridker, Paul M., Ingelsson, Erik, Laakso, Markku, Hansen, Torben, Qi, Lu, Wareham, Nicholas J., Chasman, Daniel I., Hallmans, Göran, Hu, Frank B., Renström, Frida, Orho-Melander, Marju, Franks, Paul W.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723486/

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