4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation

4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation

Recent studies have proposed that n-3 polyunsaturated fatty acids (n-3 PUFAs) have direct antioxidant and anti-inflammatory effects in vascular tissue, explaining their cardioprotective effects. However, the molecular mechanisms are not yet fully understood. We tested whether n-3 PUFAs showed antiox...

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Bibliographic Details
Main Authors: Ishikado, Atsushi, Morino, Katsutaro, Nishio, Yoshihiko, Nakagawa, Fumiyuki, Mukose, Atsushi, Sono, Yoko, Yoshioka, Nagisa, Kondo, Keiko, Sekine, Osamu, Yoshizaki, Takeshi, Ugi, Satoshi, Uzu, Takashi, Kawai, Hiromichi, Makino, Taketoshi, Okamura, Tomio, Yamamoto, Masayuki, Kashiwagi, Atsunori, Maegawa, Hiroshi
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720569/

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