GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice

GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice

Peroxisome proliferator-activated receptors (PPARs) are a nuclear receptor family of ligand-inducible transcription factors, which have three different isoforms: PPARα, δ and γ. It has been demonstrated that PPARα and γ agonists have renoprotective effects in proteinuric kidney diseases; however, th...

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Bibliographic Details
Main Authors: Yang, Xu, Kume, Shinji, Tanaka, Yuki, Isshiki, Keiji, Araki, Shin-ichi, Chin-Kanasaki, Masami, Sugimoto, Toshiro, Koya, Daisuke, Haneda, Masakazu, Sugaya, Takeshi, Li, Detian, Han, Ping, Nishio, Yoshihiko, Kashiwagi, Atsunori, Maegawa, Hiroshi, Uzu, Takashi
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178624/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178624/

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