Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly

In the present study, we tested whether elderly with a high dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) would have higher cognitive test scores and greater brain volume than those with low dietary intake of these fatty acids. Data were obtained from the Prospective I...

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Main Authors:	Titova, Olga E., Sjögren, Per, Brooks, Samantha J., Kullberg, Joel, Ax, Erika, Kilander, Lena, Riserus, Ulf, Cederholm, Tommy, Larsson, Elna-Marie, Johansson, Lars, Ahlström, Håkan, Lind, Lars, Schiöth, Helgi B., Benedict, Christian
Format:	Online
Language:	English
Published:	Springer Netherlands 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705118/

id	pubmed-3705118
recordtype	oai_dc
spelling	pubmed-37051182013-07-11 Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly Titova, Olga E. Sjögren, Per Brooks, Samantha J. Kullberg, Joel Ax, Erika Kilander, Lena Riserus, Ulf Cederholm, Tommy Larsson, Elna-Marie Johansson, Lars Ahlström, Håkan Lind, Lars Schiöth, Helgi B. Benedict, Christian Article In the present study, we tested whether elderly with a high dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) would have higher cognitive test scores and greater brain volume than those with low dietary intake of these fatty acids. Data were obtained from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. The dietary intake of EPA and DHA was determined by a 7-day food protocol in 252 cognitively healthy elderly (122 females) at the age of 70 years. At age 75, participants' global cognitive function was examined, and their brain volumes were measured by magnetic resonance imaging (MRI). Three different multivariate linear regression models were applied to test our hypothesis: model A (adjusted for gender and age), model B (additionally controlled for lifestyle factors, e.g., education), and model C (further controlled for cardiometabolic factors, e.g., systolic blood pressure). We found that the self-reported 7-day dietary intake of EPA and DHA at the age of 70 years was positively associated with global gray matter volume (P < 0.05, except for model C) and increased global cognitive performance score (P < 0.05). However, no significant associations were observed between the dietary intake of EPA and DHA and global white matter, total brain volume, and regional gray matter, respectively. Further, no effects were observed when examining cognitively impaired (n = 27) elderly as separate analyses. These cross-sectional findings suggest that dietary intake of EPA and DHA may be linked to improved cognitive health in late life but must be confirmed in patient studies. Springer Netherlands 2012-07-13 2013-08 /pmc/articles/PMC3705118/ /pubmed/22791395 http://dx.doi.org/10.1007/s11357-012-9453-3 Text en © The Author(s) 2012
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Titova, Olga E. Sjögren, Per Brooks, Samantha J. Kullberg, Joel Ax, Erika Kilander, Lena Riserus, Ulf Cederholm, Tommy Larsson, Elna-Marie Johansson, Lars Ahlström, Håkan Lind, Lars Schiöth, Helgi B. Benedict, Christian
spellingShingle	Titova, Olga E. Sjögren, Per Brooks, Samantha J. Kullberg, Joel Ax, Erika Kilander, Lena Riserus, Ulf Cederholm, Tommy Larsson, Elna-Marie Johansson, Lars Ahlström, Håkan Lind, Lars Schiöth, Helgi B. Benedict, Christian Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
author_facet	Titova, Olga E. Sjögren, Per Brooks, Samantha J. Kullberg, Joel Ax, Erika Kilander, Lena Riserus, Ulf Cederholm, Tommy Larsson, Elna-Marie Johansson, Lars Ahlström, Håkan Lind, Lars Schiöth, Helgi B. Benedict, Christian
author_sort	Titova, Olga E.
title	Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
title_short	Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
title_full	Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
title_fullStr	Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
title_full_unstemmed	Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
title_sort	dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
description	In the present study, we tested whether elderly with a high dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) would have higher cognitive test scores and greater brain volume than those with low dietary intake of these fatty acids. Data were obtained from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. The dietary intake of EPA and DHA was determined by a 7-day food protocol in 252 cognitively healthy elderly (122 females) at the age of 70 years. At age 75, participants' global cognitive function was examined, and their brain volumes were measured by magnetic resonance imaging (MRI). Three different multivariate linear regression models were applied to test our hypothesis: model A (adjusted for gender and age), model B (additionally controlled for lifestyle factors, e.g., education), and model C (further controlled for cardiometabolic factors, e.g., systolic blood pressure). We found that the self-reported 7-day dietary intake of EPA and DHA at the age of 70 years was positively associated with global gray matter volume (P < 0.05, except for model C) and increased global cognitive performance score (P < 0.05). However, no significant associations were observed between the dietary intake of EPA and DHA and global white matter, total brain volume, and regional gray matter, respectively. Further, no effects were observed when examining cognitively impaired (n = 27) elderly as separate analyses. These cross-sectional findings suggest that dietary intake of EPA and DHA may be linked to improved cognitive health in late life but must be confirmed in patient studies.
publisher	Springer Netherlands
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705118/
_version_	1611993006136623104

Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly

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