Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

The transcription factor Prdm14 is a critical regulator of pluripotency and germline development. This study shows that Prdm14 represses DNA methylation and FGF signaling, thereby promoting both germ cell fate and naive pluripotency in ESC.

Bibliographic Details
Main Authors: Grabole, Nils, Tischler, Julia, Hackett, Jamie A, Kim, Shinseog, Tang, Fuchou, Leitch, Harry G, Magnúsdóttir, Erna, Surani, M Azim
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701237/
id pubmed-3701237
recordtype oai_dc
spelling pubmed-37012372013-07-05 Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation Grabole, Nils Tischler, Julia Hackett, Jamie A Kim, Shinseog Tang, Fuchou Leitch, Harry G Magnúsdóttir, Erna Surani, M Azim Scientific Reports The transcription factor Prdm14 is a critical regulator of pluripotency and germline development. This study shows that Prdm14 represses DNA methylation and FGF signaling, thereby promoting both germ cell fate and naive pluripotency in ESC. Nature Publishing Group 2013-07 2013-05-14 /pmc/articles/PMC3701237/ /pubmed/23670199 http://dx.doi.org/10.1038/embor.2013.67 Text en Copyright © 2013, European Molecular Biology Organization http://creativecommons.org/licenses/by/3.0 This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Grabole, Nils
Tischler, Julia
Hackett, Jamie A
Kim, Shinseog
Tang, Fuchou
Leitch, Harry G
Magnúsdóttir, Erna
Surani, M Azim
spellingShingle Grabole, Nils
Tischler, Julia
Hackett, Jamie A
Kim, Shinseog
Tang, Fuchou
Leitch, Harry G
Magnúsdóttir, Erna
Surani, M Azim
Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
author_facet Grabole, Nils
Tischler, Julia
Hackett, Jamie A
Kim, Shinseog
Tang, Fuchou
Leitch, Harry G
Magnúsdóttir, Erna
Surani, M Azim
author_sort Grabole, Nils
title Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
title_short Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
title_full Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
title_fullStr Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
title_full_unstemmed Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
title_sort prdm14 promotes germline fate and naive pluripotency by repressing fgf signalling and dna methylation
description The transcription factor Prdm14 is a critical regulator of pluripotency and germline development. This study shows that Prdm14 represses DNA methylation and FGF signaling, thereby promoting both germ cell fate and naive pluripotency in ESC.
publisher Nature Publishing Group
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701237/
_version_ 1611991743426723840

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