Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

The transcription factor Prdm14 is a critical regulator of pluripotency and germline development. This study shows that Prdm14 represses DNA methylation and FGF signaling, thereby promoting both germ cell fate and naive pluripotency in ESC.

Bibliographic Details
Main Authors: Grabole, Nils, Tischler, Julia, Hackett, Jamie A, Kim, Shinseog, Tang, Fuchou, Leitch, Harry G, Magnúsdóttir, Erna, Surani, M Azim
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701237/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701237/

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