Guanylate cyclase C signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect
Acute infectious and chronic diarrheal diseases are important public health problems. A recent study by Fiskerstrand and colleagues identified a family with a rare early onset familial diarrhea. By linkage analysis and exon sequencing, the authors identified a heterozygous missense mutation in GUCY2...
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| Format: | Online |
| Language: | English |
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BioMed Central
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698531/ |
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pubmed-3698531 |
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pubmed-36985312013-07-02 Guanylate cyclase C signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect Camilleri, Michael Research Highlight Acute infectious and chronic diarrheal diseases are important public health problems. A recent study by Fiskerstrand and colleagues identified a family with a rare early onset familial diarrhea. By linkage analysis and exon sequencing, the authors identified a heterozygous missense mutation in GUCY2C, encoding the guanylate cyclase C receptor, which is involved in intestinal secretion. This newly identified gene in the etiology of a familial diarrhea provides a candidate target for the development not only of new treatments for diarrhea, but also of a new drug class to treat constipation. BioMed Central 2012-06-26 /pmc/articles/PMC3698531/ /pubmed/22734671 http://dx.doi.org/10.1186/gm349 Text en Copyright ©2012 BioMed Central Ltd. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Camilleri, Michael |
| spellingShingle |
Camilleri, Michael Guanylate cyclase C signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect |
| author_facet |
Camilleri, Michael |
| author_sort |
Camilleri, Michael |
| title |
Guanylate cyclase C signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect |
| title_short |
Guanylate cyclase C signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect |
| title_full |
Guanylate cyclase C signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect |
| title_fullStr |
Guanylate cyclase C signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect |
| title_full_unstemmed |
Guanylate cyclase C signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect |
| title_sort |
guanylate cyclase c signaling: an intestinal secretory pathway where bugs, genes and new drugs intersect |
| description |
Acute infectious and chronic diarrheal diseases are important public health problems. A recent study by Fiskerstrand and colleagues identified a family with a rare early onset familial diarrhea. By linkage analysis and exon sequencing, the authors identified a heterozygous missense mutation in GUCY2C, encoding the guanylate cyclase C receptor, which is involved in intestinal secretion. This newly identified gene in the etiology of a familial diarrhea provides a candidate target for the development not only of new treatments for diarrhea, but also of a new drug class to treat constipation. |
| publisher |
BioMed Central |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698531/ |
| _version_ |
1611990999925522432 |