Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver☆☆☆★

Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver☆☆☆★

Poor prenatal nutrition, acting through epigenetic processes, induces persistent changes in offspring phenotype. We investigated the effect of maternal fat intake on polyunsaturated fatty acid (PUFA) status and on the epigenetic regulation of Fads2, encoding Δ6 desaturase (rate limiting in PUFA synt...

Full description

Bibliographic Details
Main Authors:	Hoile, Samuel P., Irvine, Nicola A., Kelsall, Christopher J., Sibbons, Charlene, Feunteun, Aurélie, Collister, Alex, Torrens, Christopher, Calder, Philip C., Hanson, Mark A., Lillycrop, Karen A., Burdge, Graham C.
Format:	Online
Language:	English
Published:	Elsevier Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698442/

Similar Items

Vascular Dysfunction Induced in Offspring by Maternal Dietary Fat Involves Altered Arterial Polyunsaturated Fatty Acid Biosynthesis
by: Kelsall, Christopher J., et al.
Published: (2012)

Dietary Protein Restriction during F0 Pregnancy in Rats Induces Transgenerational Changes in the Hepatic Transcriptome in Female Offspring
by: Hoile, Samuel P., et al.
Published: (2011)

Supplementation with N-3 Long-Chain Polyunsaturated Fatty Acids or Olive Oil in Men and Women with Renal Disease Induces Differential Changes in the DNA Methylation of FADS2 and ELOVL5 in Peripheral Blood Mononuclear Cells
by: Hoile, Samuel P., et al.
Published: (2014)

Progressive, Transgenerational Changes in Offspring Phenotype and Epigenotype following Nutritional Transition
by: Burdge, Graham C., et al.
Published: (2011)

Fat and Carbohydrate Intake over Three Generations Modify Growth, Metabolism and Cardiovascular Phenotype in Female Mice in an Age-Related Manner
by: Hoile, Samuel P., et al.
Published: (2015)

Dibromido(6,6′-dimethyl-2,2′-bipyridine-κ2 N,N′)cadmium
by: Shirvan, Sadif A., et al.
Published: (2012)

N 4,N 6-Dimethyl-N 4,N 6-diphenylpyrimidine-4,5,6-triamine
by: Shi, Fuqiang, et al.
Published: (2011)

N 4,N 6-Dimethyl-5-nitro-N 4,N 6-diphenylpyrimidine-4,6-diamine
by: Shi, Fuqiang, et al.
Published: (2011)

Dibromido(6,6′-dimethyl-2,2′-bipyridine-κ2 N,N′)cobalt(II)
by: Shirvan, Sadif A., et al.
Published: (2012)

N,N,N′,N′-Tetraethylpyridine-2,6-dicarboxamide
by: Pojarová, Michaela, et al.
Published: (2011)

N,N′-Diethyl-N,N′-diphenylpyridine-2,6-dicarboxamide
by: Klepetářová, Blanka, et al.
Published: (2012)

(2,2′-Bipyridine-6,6′-dicarboxylato-κ3 N,N′,O 6)(6′-carboxy-2,2′-bipyridine-6-carboxylato-κ3 N,N′,O 6)cobalt(III)
by: Wang, Huimin, et al.
Published: (2012)

(2,2′-Bipyridine-6,6′-dicarboxylato-κ3 N,N′,O 6)(6′-carboxy-2,2′-bipyridine-6-carboxylato-κ3 N,N′,O 6)rhodium(III)
by: Wang, Huimin, et al.
Published: (2012)

N,N,N′,N′-Tetraisobutylpyridine-2,6-dicarboxamide
by: Pojarová, Michaela, et al.
Published: (2011)

Functional Desaturase Fads1 (Δ5) and Fads2 (Δ6) Orthologues Evolved before the Origin of Jawed Vertebrates
by: Castro, Luís Filipe Costa, et al.
Published: (2012)

(6,6′-Dimethyl-2,2′-bipyridine-κ2 N,N′)diiodidomercury(II)
by: Alizadeh, Robabeh, et al.
Published: (2011)

Low central nervous system penetration of N2,N4,N6,-trihydroxymethyl-N2,N4,N6,-trimethylmelamine (Trimelamol): a cytotoxic s-triazine with reduced neurotoxicity.
by: Judson, I. R., et al.
Published: (1986)

Diet, Nutrition and Modulation of Genomic Expression in Fetal Origins of Adult Disease
by: Jackson, Alan A., et al.
Published: (2011)

Fads: segmenting the fad‐buyer market
by: Bryan, Lilly, et al.
Published: (2003)

N-(2,6-Dimethylphenyl)-N′-propanoylthiourea
by: Yusof, Mohd Sukeri Mohd, et al.
Published: (2012)

Dichlorido(4′-ferrocenyl-2,2′:6′,2′′-terpyridine-κ3 N,N′,N′′)zinc acetonitrile monosolvate
by: Tang, Si-Ping, et al.
Published: (2011)

N,N′-Dicyclohexyl-N′′-(2,6-difluorobenzoyl)-N,N′-dimethylphosphoric triamide
by: Pourayoubi, Mehrdad, et al.
Published: (2011)

Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study
by: Price, R. Jordan, et al.
Published: (2016)

Dibromido(dimethyl sulfoxide-κO)(6-methyl-2,2′-bipyridine-κ2 N,N′)cadmium
by: Shirvan, Sadif A., et al.
Published: (2012)

Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B
by: Brunet, Aurélie, et al.
Published: (2014)

[2,6-Bis(6-methylquinolin-2-yl)pyridine-kappa N-3,N `,N `']dichloridoiron(II)
by: Li, Xiao-Ping, et al.
Published: (2010)

[2,6-Bis(6-methylquinolin-2-yl)pyridine-kappa N-3,N `,N `']dichloridomanganese(II)
by: Li, Xiao-Ping, et al.
Published: (2010)

N 2,N 2,N 6,N 6-Tetrakis(2,3,4,5,6-pentafluorobenzoyl)pyridine-2,6-diamine
by: Valkonen, Arto, et al.
Published: (2011)

N,N,N′,N′-Tetrabenzyl-N′′-(2,6-difluorobenzoyl)phosphoric triamide
by: Raissi Shabari, Akbar, et al.
Published: (2012)

Dibromido(6-methyl-2,2′-bipyridine-κ2 N,N′)cobalt(II)
by: Shirvan, Sadif A., et al.
Published: (2012)

Trichlorido(6-methyl-2,2′-bipyridine-κ2 N,N′)(dimethylsulfoxide-κO)indium(III)
by: Shirvan, Sadif A., et al.
Published: (2012)

Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 (N6AMT1) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity
by: Ren, Xuefeng, et al.
Published: (2011)

Binding of benzidine, N-acetylbenzidine, N, N'-diacetylbenzidine and Direct Blue 6 to rat liver DNA.
by: Martin, C N, et al.
Published: (1983)

Discovery of the β-barrel–type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs
by: Kimura, Satoshi, et al.
Published: (2014)

N-(2,6-Dimethylphenyl)-2,2-diphenylacetamide
by: Fun, Hoong-Kun, et al.
Published: (2012)

Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18
by: Jeyanathan, Jeyamalar, et al.
Published: (2016)

FTO-Mediated Formation of N6-Hydroxymethyladenosine and N6-Formyladenosine in Mammalian RNA
by: Fu, Ye, et al.
Published: (2013)

Editorial vol 6 n 2
by: Salvatore Settineri
Published: (2018-08-01)

Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years
by: Pike, Katharine C., et al.
Published: (2012)

Interaction between Maternal and Offspring Diet to Impair Vascular Function and Oxidative Balance in High Fat Fed Male Mice
by: Torrens, Christopher, et al.
Published: (2012)