Predicting protein interactions via parsimonious network history inference

Predicting protein interactions via parsimonious network history inference

Motivation: Reconstruction of the network-level evolutionary history of protein–protein interactions provides a principled way to relate interactions in several present-day networks. Here, we present a general framework for inferring such histories and demonstrate how it can be used to determine wha...

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Main Authors: Patro, Rob, Kingsford, Carl
Format: Online
Language:English
Published: Oxford University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694678/
id pubmed-3694678
recordtype oai_dc
spelling pubmed-36946782013-06-27 Predicting protein interactions via parsimonious network history inference Patro, Rob Kingsford, Carl Ismb/Eccb 2013 Proceedings Papers Committee July 21 to July 23, 2013, Berlin, Germany Motivation: Reconstruction of the network-level evolutionary history of protein–protein interactions provides a principled way to relate interactions in several present-day networks. Here, we present a general framework for inferring such histories and demonstrate how it can be used to determine what interactions existed in the ancestral networks, which present-day interactions we might expect to exist based on evolutionary evidence and what information extant networks contain about the order of ancestral protein duplications. Oxford University Press 2013-07-01 2013-06-19 /pmc/articles/PMC3694678/ /pubmed/23812989 http://dx.doi.org/10.1093/bioinformatics/btt224 Text en © The Author 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Patro, Rob
Kingsford, Carl
spellingShingle Patro, Rob
Kingsford, Carl
Predicting protein interactions via parsimonious network history inference
author_facet Patro, Rob
Kingsford, Carl
author_sort Patro, Rob
title Predicting protein interactions via parsimonious network history inference
title_short Predicting protein interactions via parsimonious network history inference
title_full Predicting protein interactions via parsimonious network history inference
title_fullStr Predicting protein interactions via parsimonious network history inference
title_full_unstemmed Predicting protein interactions via parsimonious network history inference
title_sort predicting protein interactions via parsimonious network history inference
description Motivation: Reconstruction of the network-level evolutionary history of protein–protein interactions provides a principled way to relate interactions in several present-day networks. Here, we present a general framework for inferring such histories and demonstrate how it can be used to determine what interactions existed in the ancestral networks, which present-day interactions we might expect to exist based on evolutionary evidence and what information extant networks contain about the order of ancestral protein duplications.
publisher Oxford University Press
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694678/
_version_ 1611990060828196864

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