Deletion of the Fission Yeast Homologue of Human Insulinase Reveals a TORC1-Dependent Pathway Mediating Resistance to Proteotoxic Stress

Deletion of the Fission Yeast Homologue of Human Insulinase Reveals a TORC1-Dependent Pathway Mediating Resistance to Proteotoxic Stress

Insulin Degrading Enzyme (IDE) is a protease conserved through evolution with a role in diabetes and Alzheimer's disease. The reason underlying its ubiquitous expression including cells lacking identified IDE substrates remains unknown. Here we show that the fission yeast IDE homologue (Iph1) m...

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Bibliographic Details
Main Authors: Beuzelin, Clémentine, Evnouchidou, Irini, Rigolet, Pascal, Cauvet-Burgevin, Anne, Girard, Pierre-Marie, Dardalhon, Delphine, Culina, Slobodan, Gdoura, Abdelaziz, van Endert, Peter, Francesconi, Stefania
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691139/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691139/

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