ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

The processing of MHC class I antigenic precursor peptides by the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 is an important event in the cell biology of antigen presentation. To date, the molecular context by which the ERAP enzymes trim precursor peptides, and how ERAPs shape peptide...

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Bibliographic Details
Main Authors: Chen, Hanna, Li, Lenong, Weimershaus, Mirjana, Evnouchidou, Irini, van Endert, Peter, Bouvier, Marlene
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981824/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981824/

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