Zscan4 restores the developmental potency of embryonic stem cells
The developmental potency of mouse embryonic stem (ES) cells, which is the ability to contribute to a whole embryo is known to deteriorate during long-term cell culture. Previously we have shown that ES cells oscillate between Zscan4- and Zscan4+ states, and the transient activation of Zscan4 is req...
Main Authors: | , , , , , , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
2013
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682791/ |