Zscan4 restores the developmental potency of embryonic stem cells

The developmental potency of mouse embryonic stem (ES) cells, which is the ability to contribute to a whole embryo is known to deteriorate during long-term cell culture. Previously we have shown that ES cells oscillate between Zscan4- and Zscan4+ states, and the transient activation of Zscan4 is req...

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Bibliographic Details
Main Authors: Amano, Tomokazu, Hirata, Tetsuya, Falco, Geppino, Monti, Manuela, Sharova, Lioudmila V., Amano, Misa, Sheer, Sarah, Hoang, Hien G., Piao, Yulan, Stagg, Carole A., Yamamizu, Kohei, Akiyama, Tomohiko, Ko, Minoru S.H.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682791/