Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis

Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis

Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for osteoarthritis due to limited understanding of osteoarthritis pathogenesis. We show that TGF–β1 is activated in the subchondral bone in response to altered mechanical loading in an anterio...

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Bibliographic Details
Main Authors: Zhen, Gehua, Wen, Chunyi, Jia, Xiaofeng, Li, Yu, Crane, Janet L., Mears, Simon C., Askin, Frederic B., Frassica, Frank J., Chang, Weizhong, Yao, Jie, Nayfeh, Tariq, Johnson, Carl, Artemov, Dmitri, Chen, Qianming, Zhao, Zhihe, Zhou, Xuedong, Cosgarea, Andrew, Carrino, John, Riley, Lee, Sponseller, Paul, Wan, Mei, Lu, William Weijia, Cao, Xu
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676689/

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