Altered Expression of ZnT10 in Alzheimer's Disease Brain

Altered Expression of ZnT10 in Alzheimer's Disease Brain

There is an increasing body of evidence suggesting that metal homeostasis is dysregulated in the pathology of Alzheimer's disease (AD). Although expression levels of several transporters belonging the SLC30 family, which comprises predominantly zinc transporters, have been studied in the AD bra...

Full description

Bibliographic Details
Main Authors:	Bosomworth, Helen J., Adlard, Paul A., Ford, Dianne, Valentine, Ruth A.
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669266/

Similar Items

Differential Subcellular Localization of the Splice Variants of the Zinc Transporter ZnT5 Is Dictated by the Different C-Terminal Regions
by: Thornton, Jared K., et al.
Published: (2011)

Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients
by: Skärstrand, H, et al.
Published: (2015)

Angiotensin II Requires Zinc and Downregulation of the Zinc Transporters ZnT3 and ZnT10 to Induce Senescence of Vascular Smooth Muscle Cells
by: Patrushev, Nikolay, et al.
Published: (2012)

Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway
by: Fujimoto, Shigeyuki, et al.
Published: (2013)

Neuroprotective effect of ZnT3 knockout on subarachnoid hemorrhage
by: Chen Duo, et al.
Published: (2018-07-01)

The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective
by: Kimura, Tomoki, et al.
Published: (2016)

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells
by: Gerber, Philipp A., et al.
Published: (2014)

Zinc Transporter 8 (ZnT8) Expression Is Reduced by Ischemic Insults: A Potential Therapeutic Target to Prevent Ischemic Retinopathy
by: DeNiro, Michael, et al.
Published: (2012)

Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison’s disease
by: Fichna, Marta, et al.
Published: (2016)

Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
by: Howson, J. M. M., et al.
Published: (2012)

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance
by: Mitchell, Ryan K., et al.
Published: (2016)

ZnT8 Is a Major CD8+ T Cell–Recognized Autoantigen in Pediatric Type 1 Diabetes
by: Énée, Émmanuelle, et al.
Published: (2012)

Neurochemical Characterization of Zinc Transporter 3-Like Immunoreactive (ZnT3+) Neurons in the Intramural Ganglia of the Porcine Duodenum
by: Wojtkiewicz, Joanna, et al.
Published: (2012)

ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice
by: Podany, Abigail B., et al.
Published: (2016)

ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions
by: Nayak, Deepak K., et al.
Published: (2014)

ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution
by: Hennigar, Stephen R., et al.
Published: (2015)

Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation
by: Yoo, Min Heui, et al.
Published: (2016)

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia
by: Solomou, Antonia, et al.
Published: (2016)

ZnT8-Specific CD4+ T Cells Display Distinct Cytokine Expression Profiles between Type 1 Diabetes Patients and Healthy Adults
by: Chujo, Daisuke, et al.
Published: (2013)

Altered expression of claudin family proteins in Alzheimer’s disease and vascular dementia brains
by: Romanitan, Mihaela O, et al.
Published: (2010)

Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study
by: Hokama, Masaaki, et al.
Published: (2014)

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
by: Nicolson, Tamara J., et al.
Published: (2009)

Interactions of metals and Apolipoprotein E in Alzheimer’s disease
by: Xu, He, et al.
Published: (2014)

Pharmacotherapeutic targets in Alzheimer's disease
by: Biran, Yif'at, et al.
Published: (2009)

Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies
by: Niegowska, Magdalena, et al.
Published: (2016)

Antibodies Recognizing Mycobacterium avium paratuberculosis Epitopes Cross-React with the Beta-Cell Antigen ZnT8 in Sardinian Type 1 Diabetic Patients
by: Masala, Speranza, et al.
Published: (2011)

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion*
by: Solomou, Antonia, et al.
Published: (2015)

Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer's disease
by: Peraza, Luis R., et al.
Published: (2015)

Metal Chaperones: A Holistic Approach to the Treatment of Alzheimer’s Disease
by: Adlard, Paul Anthony, et al.
Published: (2012)

Apical Localization of Zinc Transporter ZnT4 in Human Airway Epithelial Cells and Its Loss in a Murine Model of Allergic Airway Inflammation
by: Murgia, Chiara, et al.
Published: (2011)

Precocious Alterations of Brain Oscillatory Activity in Alzheimer’s Disease: A Window of Opportunity for Early Diagnosis and Treatment
by: Hamm, Valentine, et al.
Published: (2015)

Glia and zinc in ageing and Alzheimer’s disease: a mechanism for cognitive decline?
by: Hancock, Sara M., et al.
Published: (2014)

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains
by: Karch, Celeste M., et al.
Published: (2012)

Peroxisomal alterations in Alzheimer’s disease
by: Kou, Jianqiu, et al.
Published: (2011)

Epigenetic Alterations in Alzheimer’s Disease
by: Sanchez-Mut, Jose V., et al.
Published: (2015)

Copper Modulation as a Therapy for Alzheimer's Disease?
by: Manso, Yasmina, et al.
Published: (2011)

Transient Neonatal Zinc Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 (SLC30A2) Gene in the Mother Highlighting the Importance of Zn2+ for Normal Growth and Development
by: Miletta, Maria Consolata, et al.
Published: (2013)

Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
by: Roberts, Blaine R., et al.
Published: (2016)

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease
by: Zhang, Liang, et al.
Published: (2016)

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain
by: Gaëlle Dominguez, et al.
Published: (2018-04-01)