To Clone or Not to Clone? Induced Pluripotent Stem Cells Can Be Generated in Bulk Culture

Induced pluripotent stem cells (iPSCs) are usually clonally derived. The selection of fully reprogrammed cells generally involves picking of individual colonies with morphology similar to embryonic stem cells (ESCs). Given that fully reprogrammed cells are highly proliferative and escape from cellul...

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Bibliographic Details
Main Authors: Willmann, Charlotte A., Hemeda, Hatim, Pieper, Lisa A., Lenz, Michael, Qin, Jie, Joussen, Sylvia, Sontag, Stephanie, Wanek, Paul, Denecke, Bernd, Schüler, Herdit M., Zenke, Martin, Wagner, Wolfgang
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667031/