Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

RNA interference (RNAi)-based therapeutics have the potential to treat chronic hepatitis B virus (HBV) infection in a fundamentally different manner than current therapies. Using RNAi, it is possible to knock down expression of viral RNAs including the pregenomic RNA from which the replicative inter...

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Bibliographic Details
Main Authors: Wooddell, Christine I, Rozema, David B, Hossbach, Markus, John, Matthias, Hamilton, Holly L, Chu, Qili, Hegge, Julia O, Klein, Jason J, Wakefield, Darren H, Oropeza, Claudia E, Deckert, Jochen, Roehl, Ingo, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Vornlocher, Hans-Peter, McLachlan, Alan, Lewis, David L
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666629/

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